2′-MOE RNA – Cartridge


The 2′-MOE RNA Cartridge is a specialized reagent cartridge designed for the Kilobaser one-XT DNA/RNA Synthesizer, enabling the synthesis of fully 2′-O-methoxyethyl (2′-MOE) modified RNA oligonucleotides. These modifications enhance duplex stability, nuclease resistance, and reduce cytotoxicity, making them suitable for various research applications.

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Key Features

  • Reagent Volume: Sufficient for synthesizing 150 nucleotides, with 75 units each of A, C, G, and mU (2′-MOE modified uridine).

  • Modification: Incorporates 2′-MOE ribonucleotides to enhance RNA duplex stability and reduce cytotoxicity.

  • Compatibility: Exclusively compatible with the Kilobaser one-XT synthesizer and requires the Standard Chip for operation.

  • Shelf Life: Stable for up to 1 year when stored at 4°C; recommended to use within 2 weeks after opening.

  • Safety: Closed system design eliminates direct contact with chemicals, enhancing user safety.

Synthesis Output

The number of oligonucleotides you can synthesize depends on their length:

  • 5 oligos of 30 bases each.

  • 6 oligos of 25 bases each.

  • 7 oligos of 20 bases each​.

Applications

  • Reagent volume for 150 2′-MOE RNA bases

  • 75 nucleotides each of A, U, C and G

  • Shelf life of 1 year

  • Store at 4°C

  • Use within 2 weeks of opening

  • No additional reagents needed

  • For research and development only, no therapeutic applications

  • This product is for use with Kilobaser one-XT only

Ideal for creating:

  • RNA Probes: Suitable for applications requiring enhanced stability and reduced cytotoxicity.

  • Antisense Oligonucleotides (ASOs): Beneficial for gene silencing studies due to increased nuclease resistance and binding affinity.

  • Structural Studies: Useful in studying RNA structures where stability is crucial.

Specifications

Download Specification sheet

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