2′-OMe RNA – Cartridge


The 2′-OMe RNA Cartridge is a specialized reagent cartridge designed for the Kilobaser one-XT DNA/RNA Synthesizer, enabling the synthesis of fully 2′-O-methyl-modified RNA oligonucleotides. These modifications enhance duplex stability, nuclease resistance, and reduce cytotoxicity, making them suitable for various research applications.

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Key Features

  • Reagent Volume: Sufficient for synthesizing 150 nucleotides, with 75 units each of A, U, C, and G.

  • Modification: Incorporates 2′-O-methyl ribonucleotides to enhance RNA duplex stability and reduce cytotoxicity.

  • Compatibility: Exclusively compatible with the Kilobaser one-XT synthesizer and requires the Standard Chip for operation.

  • Shelf Life: Stable for up to 1 year when stored at 4°C; recommended to use within 2 weeks after opening.

  • Safety: Closed system design eliminates direct contact with chemicals, enhancing user safety.

Synthesis Output

The number of oligonucleotides you can synthesize depends on their length:

  • 5 oligos of 30 bases each

  • 6 oligos of 25 bases each

  • 7 oligos of 20 bases each

 Applications

Ideal for creating:

  • RNA Probes: Suitable for applications requiring enhanced stability and reduced cytotoxicity.

  • Antisense Oligonucleotides (ASOs): Beneficial for gene silencing studies due to increased nuclease resistance and binding affinity.

  • Structural Studies: Useful in studying RNA structures where stability is crucial.

Specifications

Download Specification sheet

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